Investigation of drug-induced cholestasis in HepaRG cells using untargeted LC-MS metabolomics

被引：0
|
作者：
Cuykx, M. [1 ,4 ]
Beirnaert, C. [2 ,3 ]
Rodrigues, R. M. [4 ]
Laukens, K. [2 ,3 ]
Vanhaecke, T. [4 ]
Covaci, A. [1 ]
机构：
[1] Univ Antwerp, Toxicol Ctr, Antwerp, Belgium
[2] Univ Antwerp, Dept Math & Comp Sci, Antwerp, Belgium
[3] Univ Antwerp, Biomed Informat Network Antwerpen, Antwerp, Belgium
[4] Vrije Univ Brussel, Res Grp Vitro Toxicol & Dermatocosmetol, Jette, Belgium
来源：
TOXICOLOGY LETTERS | 2018年 / 295卷
关键词：
D O I：
10.1016/j.toxlet.2018.06.050
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
OP01-04
引用
收藏
页码：S57 / S57
页数：1
相关论文
共 50 条
  • [1] LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
    Carlos Garcia-Canaveras, Juan
    Jimenez, Nuria
    Jose Gomez-Lechon, M.
    Castell, Jose V.
    Teresa Donato, M.
    Lahoz, Agustin
    [J]. ELECTROPHORESIS, 2015, 36 (18) : 2294 - 2302
  • [2] Filtering procedures for untargeted LC-MS metabolomics data
    Schiffman, Courtney
    Petrick, Lauren
    Perttula, Kelsi
    Yano, Yukiko
    Carlsson, Henrik
    Whitehead, Todd
    Metayer, Catherine
    Hayes, Josie
    Rappaport, Stephen
    Dudoit, Sandrine
    [J]. BMC BIOINFORMATICS, 2019, 20 (1)
  • [3] Filtering procedures for untargeted LC-MS metabolomics data
    Courtney Schiffman
    Lauren Petrick
    Kelsi Perttula
    Yukiko Yano
    Henrik Carlsson
    Todd Whitehead
    Catherine Metayer
    Josie Hayes
    Stephen Rappaport
    Sandrine Dudoit
    [J]. BMC Bioinformatics, 20
  • [4] Untargeted liquid chromatography-mass spectrometry metabolomics to assess drug-induced cholestatic features in HepaRG® cells
    Cuykx, Matthias
    Beirnaert, Charlie
    Rodrigues, Robim M.
    Laukens, Kris
    Vanhaecke, Tamara
    Covaci, Adrian
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 379
  • [5] Integration of GC-MS and LC-MS for untargeted metabolomics profiling
    Zeki, Ozge Cansin
    Eylem, Cemil Can
    Recber, Tuba
    Kir, Sedef
    Nemutlu, Emirhan
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 190
  • [6] Network Marker Selection for Untargeted LC-MS Metabolomics Data
    Cai, Qingpo
    Alvarez, Jessica A.
    Kang, Jian
    Yu, Tianwei
    [J]. JOURNAL OF PROTEOME RESEARCH, 2017, 16 (03) : 1261 - 1269
  • [7] Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics
    Wang, Lin
    Xing, Xi
    Chen, Li
    Yang, Lifeng
    Su, Xiaoyang
    Rabitz, Herschel
    Lu, Wenyun
    Rabinowitz, Joshua D.
    [J]. ANALYTICAL CHEMISTRY, 2019, 91 (03) : 1838 - 1846
  • [8] Deep annotation of untargeted LC-MS metabolomics data with Binner
    Kachman, Maureen
    Habra, Hani
    Duren, William
    Wigginton, Janis
    Sajjakulnukit, Peter
    Michailidis, George
    Burant, Charles
    Karnovsky, Alla
    [J]. BIOINFORMATICS, 2020, 36 (06) : 1801 - 1806
  • [9] Challenges and emergent solutions for LC-MS/MS based untargeted metabolomics in diseases
    Cui, Liang
    Lu, Haitao
    Lee, Yie Hou
    [J]. MASS SPECTROMETRY REVIEWS, 2018, 37 (06) : 772 - 792
  • [10] Comparative metabolite fingerprinting of chia, flax and sesame seeds using LC-MS untargeted metabolomics
    Brigante, Federico, I
    Podio, Natalia S.
    Wunderlin, Daniel A.
    Baroni, Maria, V
    [J]. FOOD CHEMISTRY, 2022, 371
12345