Biocompatible glutathione capped gold clusters as one- and two-photon excitation fluorescence contrast agents for live cells imaging

被引：195
|
作者：
Polavarapu, Lakshminarayana [1 ]
Manna, Manoj [1 ]
Xu, Qing-Hua [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
来源：
NANOSCALE | 2011年 / 3卷 / 02期
关键词：
SEMICONDUCTOR QUANTUM DOTS; IN-VITRO; NANOPARTICLES; LUMINESCENCE; NANORODS; CYTOTOXICITY; ABSORPTION; CANCER; SIZE; NANOCLUSTERS;
D O I：
10.1039/c0nr00458h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The one- and two-photon excitation emission properties of water soluble glutathione monolayer protected gold clusters were investigated. Strong two-photon emission was observed from the gold clusters. The two-photon absorption cross section of these gold clusters in water was deduced from the z-scan measurement to be 189 740 GM, which is much higher compared to organic fluorescent dyes and quantum dots. These gold clusters also showed high photo-stability. The MTT assay showed that these gold clusters have low toxicity even at high concentrations. We have successfully demonstrated their applications for both one and two-photon excitation live cell imaging. The exceptional properties of these gold clusters make them a promising alternative for one- and two-photon bio-imaging and other nonlinear optical applications.
引用
收藏
页码：429 / 434
页数：6
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