FeCl3-promoted tandem 1,4-conjugate addition/6-endo-dig cyclization/oxidation of propargylamines and benzoylacetonitriles/malononitriles: direct access to functionalized 2-aryl-4H-chromenes

被引：23

作者：

He, Xinwei ^{[1
]}

Wang, Hui ^{[1
]}

Cai, Xiaoting ^{[1
]}

Li, Qianqian ^{[1
]}

Tao, Jiajia ^{[1
]}

Shang, Yongjia ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, State Key Lab Cultivat Base, Key Lab Funct Mol Solids,Minist Educ,Anhui Lab Mo, Wuhu 241000, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 39期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; POLYSUBSTITUTED PYRROLES; ANTIMICROBIAL ACTIVITY; 3-COMPONENT SYNTHESIS; CATALYZED REACTIONS; BETA-ENAMINONES; DOMINO REACTION; DERIVATIVES;

D O I：

10.1039/c8ob01927d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and concise procedure has been developed for the synthesis of functionalized 2-aryl-4H-chromenes based on a tandem reaction of propargylamines and benzoylacetonitriles/malononitriles in the presence of FeCl3 as an environmentally friendly promoter. This reaction involves a highly efficient tandem sequence consisting of 1,4-conjugate addition, 6-endo-dig cyclization, and oxidation. This protocol tolerates a variety of functional groups, thereby providing a practical and efficient method for the fabrication of 2-aryl-4H-chromene skeletons.

引用

页码：7191 / 7202

页数：12