Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals

被引：0

作者：

Kosmicki, Jack A. ^{[1
]}

Horowitz, Julie E. ^{[1
]}

Banerjee, Nilanjana ^{[1
]}

Lanche, Rouel ^{[1
]}

Marcketta, Anthony ^{[1
]}

Maxwell, Evan ^{[1
]}

Bai, Xiaodong ^{[1
]}

Sun, Dylan ^{[1
]}

Backman, Joshua D. ^{[1
]}

Sharma, Deepika ^{[1
]}

Kury, Fabricio S. P. ^{[1
]}

Kang, Hyun M. ^{[1
]}

O'Dushlaine, Colm ^{[1
]}

Yadav, Ashish ^{[1
]}

Mansfield, Adam J. ^{[1
]}

Li, Alexander H. ^{[1
]}

Watanabe, Kyoko ^{[11
]}

Gurski, Lauren ^{[1
]}

McCarthy, Shane E. ^{[1
]}

Locke, Adam E. ^{[1
]}

Khalid, Shareef ^{[1
]}

O'Keeffe, Sean ^{[1
]}

Mbatchou, Joelle ^{[1
]}

Chazara, Olympe ^{[2
]}

Huang, Yunfeng ^{[3
]}

Kvikstad, Erika ^{[5
]}

O'Neill, Amanda ^{[2
]}

Nioi, Paul ^{[4
]}

Parker, Meg M. ^{[4
]}

Petrovski, Slave ^{[2
]}

Runz, Heiko ^{[3
]}

Szustakowski, Joseph D. ^{[5
]}

Wang, Quanli ^{[2
]}

Wong, Emily ^{[6
]}

Cordova-Palomera, Aldo ^{[6
]}

Smith, Erin N. ^{[6
]}

Szalma, Sandor ^{[6
]}

Zheng, Xiuwen ^{[7
]}

Esmaeeli, Sahar ^{[7
]}

Davis, Justin W. ^{[7
]}

Lai, Yi-Pin ^{[8
]}

Chen, Xing ^{[8
]}

Justice, Anne E. ^{[9
]}

Leader, Joseph B. ^{[9
]}

Mirshahi, Tooraj ^{[9
]}

Carey, David J. ^{[9
]}

Verma, Anurag ^{[10
]}

Sirugo, Giorgio ^{[10
]}

Ritchie, Marylyn D. ^{[10
]}

Rader, Daniel J. ^{[10
]}

机构：

[1] Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA

[2] AstraZeneca, Ctr Genom Res, Discovery Sci, BioPharmaceut R&D, Cambridge CB2 0AA, England

[3] Biogen Inc, 300 Binney St, Cambridge, MA 02142 USA

[4] Alnylam Pharmaceut, 675 West Kendall St, Cambridge, MA 02142 USA

[5] Bristol Myers Squibb, Route 206 & Prov Line Rd, Princeton, NJ 08543 USA

[6] Takeda Calif Inc, 9625 Towne Ctr Dr, San Diego, CA 92121 USA

[7] AbbVie Inc, 1 N Waukegan Rd, N Chicago, IL 60064 USA

[8] Pfizer Inc, 1 Portland St, Cambridge, MA 02139 USA

[9] Geisinger, Danville, PA 17822 USA

[10] Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[11] Columbia Univ, Irving Med Ctr, Inst Genom Med, New York, NY 10032 USA

[12] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

[13] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Nephrol, New York, NY 10032 USA

[14] Univ Edinburgh, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland

[15] Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

[16] Genom England, London EC1M 6BQ, England

[17] Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland

[18] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

[19] Great Ormond St Hosp Children NHS Fdn Trust, London WC1N 3JH, England

[20] Royal Infirm Edinburgh NHS Trust, Intens Care Unit, 54 Little France Dr, Edinburgh EH16 5SA, Midlothian, Scotland

[21] Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[22] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ H3A 0G4, Canada

[23] McGill Univ, Dept Human Genet, Montreal, PQ H3A 0G4, Canada

[24] Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto 6068501, Japan

[25] McGill Univ, Canada Canadian Ctr Computat Genom, Montreal, PQ H3A 0G4, Canada

[26] Kings Coll London, Dept Twins Res, London WC2R 2LS, England

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2021年 / 108卷 / 07期

关键词：

NEW-YORK-CITY; SARS-COV-2;

D O I：

10.1016/j.ajhg.2021.017

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, and results are publicly available through the Regeneron Genetics Center COVID-19 Results Browser.

引用

页码：1350 / 1355

页数：6

共 16 条

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