The biological basis of limbal stem cell deficiency

被引：0
|
作者：
Thomasen, H. [1 ]
Steuhl, K. -P. [1 ]
Meller, D. [1 ]
机构：
[1] Univ Klinikum Essen, Zentrum Augenheilkunde, Klin Erkrankungen Vorderen Augenabschnitts, D-45147 Essen, Germany
来源：
OPHTHALMOLOGE | 2012年 / 109卷 / 09期
关键词：
Limbal stem cells; Limbal progenitor cells; Limbal stem cell niche; Regulation; Limbal stem cell deficiency; CORNEAL EPITHELIAL MAINTENANCE; STEM/PROGENITOR CELLS; AMNIOTIC MEMBRANE; OCULAR SURFACE; NICHE; DIFFERENTIATION; PROLIFERATION; DELTA-NP63; EXPRESSION; HYPOTHESIS;
D O I：
10.1007/s00347-011-2507-6
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Limbal stem cell deficiency results from the loss of tissue regenerating stem and progenitor cells. Corneal epithelial regeneration is maintained by stem and progenitor cells which reside in the schlerocorneal limbus. They possess stem cell characteristics and can be stimulated to proliferate by external signals. The limbus is the stem cell niche for corneal epithelial stem cells and forms a unique microenvironment in which stem cell characteristics are conserved. Regulation of limbal epithelial stem cells is produced by a network of signals within the niche which governs cell fate decisions with regards to proliferation, differentiation or maintenance of a quiescent status.
引用
收藏
页码：843 / +
页数：6
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