Discovery and in vitro evaluation of potent kinase inhibitors:: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines

被引：31

作者：

Alberti, MJ ^{[1
]}

Auten, EP ^{[1
]}

Lackey, KE ^{[1
]}

McDonald, OB ^{[1
]}

Wood, ER ^{[1
]}

Preugschat, F ^{[1
]}

Cutler, GJ ^{[1
]}

Kane-Carson, L ^{[1
]}

Liu, W ^{[1
]}

Jung, DK ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 16期

关键词：

kinase inhibitor; VEGFR; GSK; Erb; EGFR;

D O I：

10.1016/j.bmcl.2005.05.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines as potent kinase inhibitors are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3778 / 3781

页数：4

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