Threefold Exposure to Moderate Hypobaric Hypoxia Decreases the Expression of Cu,Zn-Superoxide Dismutase in Some Regions of Rat Hippocampus

被引：3
|
作者：
Stroev, S. A. [1 ,2 ]
Tyul'kova, E. I. [1 ]
Pelto-Huikko, M. T. [2 ]
Samoilov, M. O. [1 ]
机构：
[1] Russian Acad Sci, IP Pavlov Physiol Inst, Lab Regulat Brain Neuron Funct, St Petersburg 196140, Russia
[2] Univ Tampere, Sch Med, Dept Dev Biol, FIN-33101 Tampere, Finland
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
Cu; Zn-superoxide dismutase; moderate hypoxia; preconditioning; COPPER/ZINC-SUPEROXIDE-DISMUTASE; FOCAL CEREBRAL-ISCHEMIA; BRAIN; PREVENTS;
D O I：
10.1007/s10517-011-1314-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of moderate hypobaric hypoxia on the expression of a peptide antioxidant Cu,Zn-superoxide dismutase in rat hippocampal neurons was evaluated in an immunocytochemical study. The expression of Cu, Zn-superoxide dismutase decreased significantly in the dorsal hippocampus (CA1 and CA2) and tended to decrease in ventral regions (CA3 and dentate gyrus) by the 24th hour after 3-fold exposure to hypoxia.
引用
收藏
页码：301 / 304
页数：4
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