Histamine Blood Concentration in Ischemic Heart Disease Patients

被引：32
|
作者：
Zdravkovic, Vladimir [1 ,2 ]
Pantovic, Suzana [1 ]
Rosic, Gvozden [1 ]
Tomic-Lucic, Aleksandra [1 ,2 ]
Zdravkovic, Nemanja [1 ]
Colic, Maja [1 ]
Obradovic, Zdravko [1 ]
Rosic, Mirko [1 ,3 ]
机构：
[1] Univ Kragujevac, Fac Med, Dept Physiol, Kragujevac 34000, Serbia
[2] Med Ctr Kragujevac, Dept Internal Med, Kragujevac 34000, Serbia
[3] Serbian Acad Arts & Sci, Res Ctr, Kragujevac 34000, Serbia
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年
关键词：
ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; CARDIAC TROPONIN-I; MAST-CELLS; NITRIC-OXIDE; PLATELET ACTIVATION; ENDOTHELIAL-CELLS; PLASMA HISTAMINE; EARLY-DIAGNOSIS; ARTERY-DISEASE;
D O I：
10.1155/2011/315709
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The aim of this study was to investigate histamine blood concentration in subjects suffering from different types of ischemic heart diseases during the period of eight days. Our results showed that the histamine blood level was associated with different types of ischemic heart diseases. The blood histamine level in all investigated patients was significantly higher when compared to control subjects (44.87 +/- 1.09 ng mL(-1)), indicating the increase of histamine release in patients suffering from coronary diseases. In patients suffering from ACS-UA and ACS-STEMI, the second day peak of histamine level occurs (90.85 +/- 6.34 ng mL(-1) and 121.7 +/- 6.34 ng mL(-1), resp.) probably as the reperfusion event. Furthermore, our data suggest that histamine can be additional parameter of myocardial ischemia along with cardiac specific enzymes and may prove to be an excellent single prognostic marker for multitude of ischemic heart diseases.
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页数：8
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