Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and Therapy

被引：78

作者：

Schirrmann, Thomas ^{[1
]}

Meyer, Torsten ^{[1
]}

Schuette, Mark ^{[1
]}

Frenzel, Andre ^{[1
]}

Hust, Michael ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Biochem & Biotechnol, Dept Biotechnol, D-38106 Braunschweig, Germany

来源：

MOLECULES | 2011年 / 16卷 / 01期

关键词：

antibody; scFv; phage display; cancer; diagnostics; proteome research; panning; AFFINITY HUMAN-ANTIBODIES; MONOCLONAL-ANTIBODIES; RECOMBINANT ANTIBODIES; RHEUMATOID-ARTHRITIS; FILAMENTOUS PHAGE; COLORECTAL-CANCER; ESCHERICHIA-COLI; TRANSGENIC MICE; GENE LIBRARIES; PHASE-II;

D O I：

10.3390/molecules16010412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty years after its development, antibody phage display using filamentous bacteriophage represents the most successful in vitro antibody selection technology. Initially, its development was encouraged by the unique possibility of directly generating recombinant human antibodies for therapy. Today, antibody phage display has been developed as a robust technology offering great potential for automation. Generation of monospecific binders provides a valuable tool for proteome research, leading to highly enhanced throughput and reduced costs. This review presents the phage display technology, application areas of antibodies in research, diagnostics and therapy and the use of antibody phage display for these applications.

引用

页码：412 / 426

页数：15

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