A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion

被引：25

作者：

Sharma, Vijay ^{[1
,2
]}

Sivapackiam, Jothilingam ^{[1
]}

Harpstrite, Scott E. ^{[1
]}

Prior, Julie L. ^{[1
]}

Gu, Hannah ^{[1
]}

Rath, Nigam P. ^{[5
]}

Piwnica-Worms, David ^{[1
,3
,4
]}

机构：

[1] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, BRIGHT Inst,Mol Imaging Ctr, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Biomed Engn, St Louis, MO USA

[3] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO USA

[5] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA

来源：

PLOS ONE | 2014年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

MDR1; P-GLYCOPROTEIN; BLOOD-BRAIN-BARRIER; MULTIDRUG-RESISTANCE; GALLIUM(III) COMPLEXES; BIOLOGICAL EVALUATION; TRANSPORT; AGENTS; METAL; TECHNETIUM-99M-SESTAMIBI; MITOCHONDRIAL;

D O I：

10.1371/journal.pone.0109361

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing Mo-99/Tc-99m generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality Ga-68, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel Ga-68-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.

引用

页数：10

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