The most vulnerable groups for cervical cancer are the poorest women, like the groups found in Argentina and Brazil. To improve this ominous situation, it is being developed a study of cervical cancer screening and control strategies. The objective of this study is to compare the performance and cost-effectiveness of Aided Visual Inspection, HPV Testing, PAP smear, Colposcopy and Cervicography in cervical cancer screening, improving understanding of epidemiology of the disease in these areas. Patients were submitted to all of these screening methods and, if necessary, colposcopy and biopsy. Patients with high-grade CIN or carcinoma were promptly treated and followed-up for 24 months. Patients with low-grade CIN, HPV infection or PAP test alteration are being followed-up until 24 months. Until 31st December 2002 we have enrolled 2755 patients. After the complete analysis of our data (n=3000) we can compare the performance characteristics and cost-effectiveness of conventional and optional screening tests in our set, also improving the understanding of this disease in our region.