Chiral induction in phenanthroline-derived oligoamide foldamers: An acid- and base-controllable switch in helical molecular strands

被引：64
|
作者：
Hu, Hai-Yu
Xiang, Jun-Feng
Yang, Yong
Chen, Chuan-Feng [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Chem Biol, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 06期
关键词：
D O I：
10.1021/ol8001688
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of phenanthroline-derived oligoamides bearing a chiral (R)-phenethylamino end group were synthesized that displayed chiral helical induction and subsequently formed one-hand helical foldamers in solution. Moreover, an acid- and base-controllable switch in the helical molecular strands was observed, which has been demonstrated by NMR, UV-vis, and circular dichroism spectroscopy.
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页码：1275 / 1278
页数：4
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