Background: Surgical site infection (SSI) is a serious complication that can occur after any orthopedic procedure. The treatment of SSI is marked by a great deal of variation, and there is little information on how to take an evidence-based approach. The goal of this research was to find risk variables for SSI treatment failure following any orthopedic surgery. Objectives: 1. The purpose of this study is to assess differences in the rates of postoperative infections in orthopedic patients undergoing surgery. 2. To correlate the association of infection with respect to urgent / emergent / elective or planned orthopedic surgeries. 3. To assess the conditions that were associated with patients proving detrimental to post-operative period. Methods: The present study is an observational, analytical, cross-sectional and prospective study, to be conducted for a duration of two years in the Department of Pathology, JNMC, Sawangi(Meghe), in coordination with the Department of General Surgery, Acharya-Vinoba-Bhave-Rural-Hospital, Sawangi(Meghe), Wardha. In this study, 50 patients who has undergone orthopedic surgeries which in the later stage develop post-operative surgical site infections and sepsis. Conclusions will be drawn and presented. Results: The observations will be depicted in a well-tabulated master chart. Conclusion: Conclusion will be drawn from the results obtained from the study.