共 50 条
- [1] MODULATING TUMOR MICROENVIRONMENT WITH ARGINASE-1 SPECIFIC T CELLSJOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A38 - A39Martinenaite, E.论文数: 0 引用数: 0 h-index: 0机构: IO Biotech, Copenhagen, Denmark IO Biotech, Copenhagen, DenmarkJoergensen, M. Aaboe论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, DenmarkMortensen, Re Johansson论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, DenmarkAhmad, S. Munir论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, Denmark论文数: 引用数: h-index:机构:Holmstrom, M. Orebo论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, DenmarkPedersen, A. Wakatsuki论文数: 0 引用数: 0 h-index: 0机构: IO Biotech, Copenhagen, Denmark IO Biotech, Copenhagen, DenmarkMet, O.论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, DenmarkSvane, I. M.论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, DenmarkAndersen, M. Hald论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Oncol, Natl Ctr Canc Immune Therapy, Herlev, Denmark IO Biotech, Copenhagen, Denmark
- [2] Peripheral memory T cells specific for Arginase-1Cellular & Molecular Immunology, 2019, 16 : 718 - 719Evelina Martinenaite论文数: 0 引用数: 0 h-index: 0机构: Copenhagen University Hospital,Center for Cancer Immune Therapy (CCIT)Shamaila Munir Ahmad论文数: 0 引用数: 0 h-index: 0机构: Copenhagen University Hospital,Center for Cancer Immune Therapy (CCIT)Inge Marie Svane论文数: 0 引用数: 0 h-index: 0机构: Copenhagen University Hospital,Center for Cancer Immune Therapy (CCIT)Mads Hald Andersen论文数: 0 引用数: 0 h-index: 0机构: Copenhagen University Hospital,Center for Cancer Immune Therapy (CCIT)
- [3] Peripheral memory T cells specific for Arginase-1CELLULAR & MOLECULAR IMMUNOLOGY, 2019, 16 (08) : 718 - 719Martinenaite, Evelina论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, CCIT, Herlev, Denmark Copenhagen Univ Hosp, CCIT, Herlev, DenmarkAhmad, Shamaila Munir论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, CCIT, Herlev, Denmark Copenhagen Univ Hosp, CCIT, Herlev, DenmarkSvane, Inge Marie论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, CCIT, Herlev, Denmark Copenhagen Univ Hosp, CCIT, Herlev, DenmarkAndersen, Mads Hald论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, CCIT, Herlev, Denmark Univ Copenhagen, Dept Immunol & Microbiol, Copenhagen, Denmark Copenhagen Univ Hosp, CCIT, Herlev, Denmark
- [4] ARGINASE-1 AND ITS ROLE IN THE GLIOBLASTOMA MICROENVIRONMENTNEURO-ONCOLOGY, 2022, 24 : 278 - 278Zamler, Daniel论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USAShingu, Takashi论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USAJiang, Shan论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USAYu, Fei论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USAJiang, Yingda论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USADraetta, Giulio论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USAHu, Jian论文数: 0 引用数: 0 h-index: 0机构: MDACC, Houston, TX USA MDACC, Houston, TX USA
- [5] CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironmentOncoImmunology, 2016, 5 (11):Martinenaite, Evelina论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkAhmad, Shamaila Munir论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkHansen, Morten论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkMet, Ozcan论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Oncol, Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkWestergaard, Marie Wulff论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkLarsen, Stine Kiaer论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkKlausen, Tobias Wirenfeldt论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkDonia, Marco论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Oncol, Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkSvane, Inge Marie论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Dept Oncol, Herlev, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, DenmarkAndersen, Mads Hald论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark Univ Copenhagen, Dept Immunol & Microbiol, Copenhagen, Denmark Copenhagen Univ Hosp, Dept Hematol, CCIT, DK-2730 Herlev, Denmark
- [6] Arginase-1 specific CD8+T cells react toward malignant and regulatory myeloid cellsONCOIMMUNOLOGY, 2024, 13 (01):Glockner, Hannah Jorinde论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkMartinenaite, Evelina论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark IO Biotech ApS, Dept Res & Dev, Copenhagen, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkLisle, Thomas Landkildehus论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkGrauslund, Jacob论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkAhmad, Shamaila论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkMet, Oezcan论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark Tech Univ Denmark, Dept Hlth Technol, Lyngby, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkStraten, Per Thor论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, DenmarkAndersen, Mads Hald论文数: 0 引用数: 0 h-index: 0机构: Copenhagen Univ Hosp, Borgmester Ib Juuls Vej 13, DK-2730 Herlev, Denmark Copenhagen Univ Hosp, Natl Ctr Canc Immune Therapy, Dept Oncol, CCIT DK, Herlev, Denmark
- [7] Ginseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironmentJournal of Experimental & Clinical Cancer Research, 42Yan Lv论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineMengyuan Li论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineLing Weng论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineHaoying Huang论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineYujie Mao论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineDanchen Aaron Yang论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineQingyun Wei论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineMengmeng Zhao论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineQin Wei论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineKe Rui论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineXuan Han论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineWeiwei Fan论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineXueting Cai论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicinePeng Cao论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western MedicineMeng Cao论文数: 0 引用数: 0 h-index: 0机构: Nanjing University of Chinese Medicine,Jiangsu Provincial Medical Innovation Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine
- [8] Ginseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironmentJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023, 42 (01)Lv, Yan论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaLi, Mengyuan论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Sch Pharm, Dept Pharmacol, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaWeng, Ling论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaHuang, Haoying论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaMao, Yujie论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaYang, Danchen Aaron论文数: 0 引用数: 0 h-index: 0机构: Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaWei, Qingyun论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaZhao, Mengmeng论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaWei, Qin论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaRui, Ke论文数: 0 引用数: 0 h-index: 0机构: Jiangsu Univ, Affiliated Hosp, Inst Med Immunol, Zhenjiang, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaHan, Xuan论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaFan, Weiwei论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaCai, Xueting论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaCao, Peng论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Sch Pharm, Dept Pharmacol, Nanjing, Jiangsu, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China Zhenjiang Hosp Chinese Tradit & Western Med, Zhenjiang, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R ChinaCao, Meng论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Jiangsu Prov Med Innovat Ctr, Nanjing, Jiangsu, Peoples R China
- [9] Possible Role of Arginase-1 in Concomitant Tumor ImmunityPLOS ONE, 2014, 9 (03):Korrer, Michael J.论文数: 0 引用数: 0 h-index: 0机构: Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA Childrens Res Inst, Milwaukee, WI USA Med Coll Wisconsin, Ctr Canc, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USARoutes, John M.论文数: 0 引用数: 0 h-index: 0机构: Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA Childrens Res Inst, Milwaukee, WI USA Med Coll Wisconsin, Ctr Canc, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA
- [10] Arginase-1 deficiencyJOURNAL OF MOLECULAR MEDICINE-JMM, 2015, 93 (12): : 1287 - 1296Sin, Yuan Yan论文数: 0 引用数: 0 h-index: 0机构: Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, CanadaBaron, Garrett论文数: 0 引用数: 0 h-index: 0机构: Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada论文数: 引用数: h-index:机构:Funk, Colin D.论文数: 0 引用数: 0 h-index: 0机构: Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada