Advances in Aspergillus secondary metabolite research in the post-genomic era

被引：202

作者：

Sanchez, James F. ^{[1
]}

Somoza, Amber D. ^{[2
]}

Keller, Nancy P. ^{[3
]}

Wang, Clay C. C. ^{[1
,2
]}

机构：

[1] Univ So Calif Pharmacol & Pharmaceut Sci, Los Angeles, CA 90033 USA

[2] Univ So Calif Chem, Los Angeles, CA USA

[3] Univ Wisconsin, Madison Med Microbiol & Immunol & Bacteriol, Madison, WI USA

来源：

NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 03期

基金：

美国国家卫生研究院;

关键词：

NONRIBOSOMAL PEPTIDE SYNTHETASE; ERGOT ALKALOID BIOSYNTHESIS; HORIZONTAL GENE-TRANSFER; POLYKETIDE SYNTHASE; TRANSCRIPTIONAL REGULATOR; GLIOTOXIN BIOSYNTHESIS; FUNCTIONAL-ANALYSIS; A BIOSYNTHESIS; DISTINCT ROLES; KOJIC ACID;

D O I：

10.1039/c2np00084a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.

引用

页码：351 / 371

页数：21

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