Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

被引：0

作者：

Alvarez-Buylla, Arturo ^{[1
,2
]}

Cebrian-Silla, Arantxa ^{[1
,2
]}

Sorrells, Shawn F. ^{[3
]}

Nascimento, Marcos Assis ^{[1
,2
]}

Paredes, Mercedes F. ^{[1
,4
]}

Garcia-Verdugo, Jose Manuel ^{[5
]}

Yang, Zhengang ^{[6
,7
]}

Huang, Eric J. ^{[1
,8
]}

机构：

[1] Univ Calif San Francisco, Eli & Edythe Broad Inst Stem Cell Res & Regenerat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[3] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Univ Valencia, Inst Cavanilles Biodiversidad & Biol Evolut, Lab Neurobiol Comparada, Ctr Invest Biorned Red Enfermedades Neurodegenera, Valencia, Spain

[6] Fudan Univ, Zhongshan Hosp, State Key Lab Med Neurobiol, Dept Neurol, Shanghai 200032, Peoples R China

[7] Fudan Univ, Zhongshan Hosp, Inst Brain Sci, Shanghai 200032, Peoples R China

[8] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

SCIENCE | 2022年 / 376卷 / 6590期

关键词：

CHILDREN;

D O I：

10.1126/science.abn8861

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin(+) astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.

引用

页数：3

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[1] Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"
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Rabano, A.
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[J]. SCIENCE, 2022, 376 (6590)
[2] Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
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