Photosensitized cleavage of the thymine dimer in DNA via carbazole nucleoside

被引：0
|
作者：
Yoshimura, Yoshinaga
Taya, Yuta
Matsumura, Hiroshi
Fujimoto, Kenzo
机构：
[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Nomi 9231292, Japan
[2] Japan Sci & Technol Agcy, Nomi 9231292, Japan
来源：
JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY | 2008年 / 21卷 / 04期
关键词：
photocleavage; thymine dimer; photosensitizer; DNA;
D O I：
10.2494/photopolymer.21.525
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We report the catalytic repair of a thymine dimer incorporated in a DNA dupl. ex via oligodeoxynucleotide (ODN) containing carbazole nucleoside. The occurrence of an electron transfer between carbazole nucleoside, and thymine dimer is evidenced by fluorescence quenching measurements. Carbazole nucleoside acts as a good electron donor for the catalytic repair of-a thymine dimer.
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页码：525 / 530
页数：6
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