A Rapid Expansion of HIV-1 CRF63_02A1 Among Newly Diagnosed HIV-Infected Individuals in the Tomsk Region, Russia

被引：0
|
作者：
Gashnikova, Natalya M. [1 ]
Bogachev, Vladislav V. [1 ]
Baryshev, Pavel B. [1 ]
Totmenin, Alexei V. [1 ]
Gashnikova, Maria P. [1 ]
Kazachinskaya, Anastasia G. [1 ]
Ismailova, Tatiana N. [2 ]
Stepanova, Svetlana A. [2 ]
Chernov, Alexander S. [2 ]
Mikheev, Valery N. [1 ]
机构：
[1] State Res Ctr Virol & Biotechnol Vector, Dept Retroviruses, Koltsov 630559, Novosibirsk Reg, Russia
[2] Tomsk Reg Ctr Prevent & Control AIDS & Other Infe, Tomsk, Russia
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2015年 / 31卷 / 04期
关键词：
TYPE-1; EPIDEMIC;
D O I：
10.1089/aid.2014.0375
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The prevalence of HIV infection in different Russian regions is nonuniform. In the Tomsk region (TR), 2020 HIV new infection cases were recorded in 2013, the morbidity having increased 5.9-fold as compared to 2012. In total, 64 blood plasma samples from primary HIV cases have been examined. HIV-specific fragments of the pol gene have been obtained for 61 samples (of protease for 58 and of integrase for 23) and of the env gene V3 region for 40 samples. Phylogenetic analysis of the determined HIV-1 sequences has detected CRF63_02A1 in 55 (90.2%) cases, whereas HIV subtype A1, characteristic of Russia, has been observed in only three (4.9%) patients. Three (4.9%) cases contain CRF63_02A1/A recombinant variants. This article demonstrates that a drastic activation of the epidemic in the Tomsk region is accompanied by a rapid spreading of the recently described HIV-1 CRF63_02A1, which we detected in the Novosibirsk region outbreak of 2008.
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收藏
页码：456 / 460
页数：5
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