A simple and highly efficient deprotecting method for methoxymethyl and methoxyethoxymethyl ethers and methoxyethoxymethyl esters

被引：0
|
作者：
Lee, ASY [1 ]
Hu, YJ [1 ]
Chu, SF [1 ]
机构：
[1] Tamkang Univ, Dept Chem, Tamsui 25137, Taiwan
来源：
TETRAHEDRON | 2001年 / 57卷 / 11期
关键词：
MEM-esters; MOM-ethers; deprotection;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of methoxyethoxymethyl (MEM)- and methoxymethyl (MOM)-ethers and MEM-esters were hydrolyzed to their corresponding alcohols and carboxylic acids by a catalytic amount of CBr4 (10%) in iPrOH under refluxing reaction condition. The chemoselective hydrolysis between R3Si- and MEM-protected alcohols can be achieved by using different steric bulkness solvents such as MeOH or iPrOH. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2121 / 2126
页数：6
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