Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report

被引：13

作者：

Nguyen, Michelle C. ^{[1
]}

Lee, Eliza J. ^{[1
]}

Avery, Robin K. ^{[2
]}

Dioverti-Prono, M. Veronica ^{[2
]}

Shoham, Shmuel ^{[2
]}

Tobian, Aaron A. R. ^{[3
]}

Bloch, Evan M. ^{[3
]}

Gurakar, Ahmet ^{[4
]}

Rizkalla, Nicole A. ^{[5
]}

Cameron, Andrew M. ^{[1
,6
]}

King, Elizabeth A. ^{[1
]}

Ottmann, Shane ^{[1
]}

Garonzik-Wang, Jacqueline M. ^{[1
,6
]}

Wesson, Russel N. ^{[1
]}

Philosophe, Benjamin ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Surg, Div Transplant Surg, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

[6] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

TRANSPLANTATION DIRECT | 2021年 / 7卷 / 08期

关键词：

SOLID-ORGAN TRANSPLANTATION; EARLY IMPACT; COVID-19;

D O I：

10.1097/TXD.0000000000001178

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes.

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页数：5

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