Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes

被引：444
|
作者：
Wu, W
Wieckowski, S
Pastorin, G
Benincasa, M
Klumpp, C
Briand, JP
Gennaro, R
Prato, M
Bianco, A [1 ]
机构：
[1] CNRS, UPR 9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France
[2] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy
[3] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 39期
关键词：
antibiotics; drug delivery; nanotubes; nanovectors; toxicity;
D O I：
10.1002/anie.200501613
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB. (Figure Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6358 / 6362
页数：5
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