Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor

被引：15

作者：

Santonocito, Rossella ^{[1
]}

Tuccitto, Nunzio ^{[1
,2
]}

Pappalardo, Andrea ^{[1
,3
]}

Sfrazzetto, Giuseppe Trusso ^{[1
,3
]}

机构：

[1] Univ Catania, Dept Chem Sci, Viale A Doria 6, I-95100 Catania, Italy

[2] Lab Mol Surfaces & Nanotechnol CSGI, I-95125 Catania, Italy

[3] Natl Interuniv Consortium Mat Sci & Technol INSTM, Res Unit Catania, I-95125 Catania, Italy

来源：

MOLECULES | 2022年 / 27卷 / 21期

关键词：

cavitand; dopamine; supramolecular; smartphone; saliva; SELECTIVE DETECTION; BETA-CYCLODEXTRIN; HOST; RECOGNITION; NEUROTRANSMITTERS; BIOSENSOR; GRAPHENE;

D O I：

10.3390/molecules27217503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Supramolecular recognition of dopamine by two quinoxaline cavitands was studied in solution by fluorescence titrations, ESI-MS and ROESY measurements. In addition, the tetraquinoxaline cavitand was dropped onto a siloxane-based polymeric solid support, obtaining a sensor able to detect dopamine in a linear range of concentrations 10 Mm-100 pM, with a detection limit of 1 pM, much lower than the normal concentration values in the common human fluids (plasma, urine and saliva), by using a simple smartphone as detector. This sensor shows also good selectivity for dopamine respect to the other common analytes contained in a saliva sample and can be reused after acid-base cycles, paving the way for the realization of real practical sensor for human dopamine detection.

引用

页数：13

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