MALDI-TOF mass spectrometry in the analysis of synthetic polymers

Matrix-assisted laser desorption/ionization mass spectrometry has been applied over the past 5 years with increasing success to the analysis of synthetic polymers. Basic principles and instrumental parameters influencing the spectra are described. Examples from different areas of polymer research with emphasis on technically relevant systems elucidate the highly useful features of this kind of mass spectrometry, i.e. determination of absolute molar masses, high mass range, reasonable mass resolution, high sensitivity, relative ease of operation even for polar molecules. Molar mass distributions can be obtained in a mass rang that is problematic for other mass determining techniques. A detailed characterization of the underlying chemistry can be obtained in many cases by an endgroup analysis. Especially in combination with other separation techniques, a comprehensive characterization of chemical heterogeneity can be achieved. Recent developments, e.g. delayed extraction to enhance the mass resolution obtainable, will further increase the favorable prospects of this technique.