Neurolytic effects of ampicillin on the rat infraorbital nerve

被引：1

作者：

Saulacic, Nikola ^{[1
]}

Lombardi, Tommaso ^{[2
]}

Stojcev-Stajcic, Ljiljana ^{[3
]}

Iizuka, Tateyuki ^{[1
]}

Stajcic, Zoran ^{[4
]}

机构：

[1] Univ Hosp Bern, Dept Craniomaxillofacial Surg, CH-3010 Bern, Switzerland

[2] Univ Geneva, Lab Oral & Maxillofacial Pathol, Div Stomatol, Geneva, Switzerland

[3] Univ Belgrade, Fac Stomatol, Clin Oral Surg, Belgrade, Serbia

[4] Dent Med Ctr Maxillofacial Surg Beograd Ctr, Belgrade, Serbia

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2012年 / 41卷 / 03期

关键词：

ampicillin; infraorbital nerve; rat; STREPTOMYCIN-LIDOCAINE INJECTIONS; TRIGEMINAL NEURALGIA; PERIPHERAL-NERVE; NEUROPATHIC PAIN; ENDONEURIAL RESPONSE; GLYCEROL; AUTOTOMY; ALCOHOL; MANAGEMENT; BLOCKADE;

D O I：

10.1111/j.1600-0714.2011.01098.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

PURPOSE: The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin. MATERIALS AND METHODS: The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy. RESULTS: Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth postoperative week. CONCLUSION: Ampicillin can cause peripheral nerve damage when injected perineurally. J Oral Pathol Med (2012) 41: 268-271

引用

页码：268 / 271

页数：4

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