Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT)

被引：48

作者：

Ozawa, Yukiyasu ^{[1
]}

Williams, Ann H. ^{[1
]}

Estes, Myka L. ^{[1
]}

Matsushita, Norimasa ^{[2
]}

Boschelli, Frank ^{[3
]}

Jove, Richard ^{[1
]}

List, Alan F. ^{[1
]}

机构：

[1] H Lee Moffitt Canc & Res Inst, Tampa, FL 33612 USA

[2] H Lee Moffitt Canc & Res Inst, Program Immunol, Tampa, FL 33612 USA

[3] Wyeth Res, Dept Oncol, Pearl River, NY USA

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 06期

关键词：

Src family kinase; STAT5; Akt;

D O I：

10.1016/j.leukres.2007.11.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viability. Akt phosphorylation and Mcl-1 expression decreased after SFK inhibition accompanied by apoptosis induction. In primary AML specimens, SFK inhibitors suppressed proliferation in 5 of 14 specimens. These data indicate that Src-STAT5 and Src-Akt pathways are integral survival signal pathways in AML cells. Src inhibition may represent a novel treatment strategy for investigation in AML. (c) 2007 Elsevier Ltd. All rights reserved.

引用

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页码：893 / 903

页数：11

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