The influence of gastrin and/or cholecystokinin antagonists on the proliferation of three human astrocytic tumor cell lines

被引：9
|
作者：
Camby, I
Salmon, I
Oiry, C
Galleyrand, JC
Nagy, N
Danguy, A
Brotchi, J
Pasteels, JL
Martinez, J
Kiss, R
机构：
[1] FREE UNIV BRUSSELS,FAC MED,HISTOL LAB,B-1070 BRUSSELS,BELGIUM
[2] FREE UNIV BRUSSELS,HOP ERASME,SERV ANATOMOPATHOL,B-1070 BRUSSELS,BELGIUM
[3] FREE UNIV BRUSSELS,HOP ERASME,SERV NEUROCHIRURG,B-1070 BRUSSELS,BELGIUM
[4] FAC PHARM MONTPELLIER,CNRS,URA 1845,LAB CHIM & PHARMACOL MOLEC INTERET BIOL,MONTPELLIER,FRANCE
来源：
NEUROPEPTIDES | 1996年 / 30卷 / 05期
关键词：
D O I：
10.1016/S0143-4179(96)90006-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We have investigated the potential role of gastrin in the regulation of cell growth in human astrocytic tumors. To this end we have used synthetic analogs of gastrin and cholecystokinin (CCK) which behave as gastrin and/or CCK antagonists, e.g. compounds JMV-97, JMV-209 and JMV-179. Their effects on astrocytic tumor cell proliferation was investigated by the use of the colorimetric MTT assay. The in vitro biological models used in the present study included the SW1088, U87 and U373 astrocytic tumor cell lines. The results demonstrated marked influence of gastrin and CCK antagonists in the regulation of astrocytic tumor growth. This suggests that gastrin and/or CCK antagonists might be tested in experimental glioblastoma.
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页码：433 / 437
页数：5
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