Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension

被引：14
|
作者：
Cvenkel, Barbara [1 ]
Stewart, Jeanette A. [2 ]
Nelson, Lindsay A. [3 ]
Stewart, William C. [2 ,4 ]
机构：
[1] Univ Eye Clin Ljubljana, Ljubljana, Slovenia
[2] PRN Pharmaceut Res Netowrk LLC, Dallas, TX USA
[3] Charleston Res Co LLC, Charleston, SC USA
[4] Univ S Carolina, Sch Med, Carolina Eye Inst, Columbia, SC 29208 USA
来源：
CURRENT EYE RESEARCH | 2008年 / 33卷 / 02期
关键词：
dorzolamide/timolol fixed combination; latanoprost/timolol fixed combination; timolol gel forming solution;
D O I：
10.1080/02713680701832480
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: The efficacy of dorzolamide/timolol fixed combination (DTFC) versus latanoprost/timolol fixed combination (LTFC) in open-angle glaucoma or ocular hypertensive patients. Methods: Patients were randomized to DTFC or LTFC for 6 weeks and switched to opposite treatment for Period 2. Results: Thirty-two completed patients had a mean diurnal IOP of 19.5 +/- 3.2 mmHg for DTFC and 18.9 +/- 3.4 mmHg for LTFC (p = 0.12), with no significant difference found between DTFC and LTFC at any timepoint following a Bonferroni correction (p >= 0.01). Conclusions: Patients treated with DTFC and LTFC have a statistically similar ocular hypotensive effect.
引用
收藏
页码：163 / 168
页数：6
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