The links between gut microbiota and obesity and obesity related diseases

被引：108

作者：

Geng, Jiafeng

Ni, Qingqiang ^{[3
]}

Sun, Wei ^{[4
]}

Li, Liangge ^{[4
]}

Feng, Xiujing ^{[1
,2
,3
,4
]}

机构：

[1] Shandong First Med Univ, Dept Endocrinol & Metabol, Affiliated Hosp 1, Jinan 250014, Peoples R China

[2] Shandong Prov QianFoshan Hosp, Shandong Key Lab Rheumat Dis & Translat Med, Shandong Inst Nephrol, Jinan 250014, Peoples R China

[3] Shandong First Med Univ, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China

[4] Shandong First Med Univ & Shandong Acad Med Sci, Sch Basic Med, Jinan 250062, Shandong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 147卷

基金：

中国国家自然科学基金;

关键词：

Obesity; Gut microbiota; Mechanism; Metabolic products; Therapy; CHAIN FATTY-ACIDS; DIET-INDUCED OBESITY; INTESTINAL MICROBIOTA; BARIATRIC SURGERY; EARLY-LIFE; FOLLOW-UP; LIPID-METABOLISM; BARRIER FUNCTION; BODY-WEIGHT; OVERWEIGHT;

D O I：

10.1016/j.biopha.2022.112678

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The obesity epidemic has become a global public health crisis in recent years and is continuing to worsen at an alarming rate. However, the pathophysiological mechanisms involved in the development of obesity and obesity related diseases are still being unraveled. In the past ten years, the gut microbiota has been identified as a crucial player affecting the onset and progression of obesity and obesity-related diseases, especially with respect to changes in its composition and metabolites during obesity progression. Herein, we summarize the roles and mechanisms of gut microbiota's composition and metabolite changes in the gut play in obesity and obesity related diseases. Furthermore, we discuss potential therapeutic treatments that can be used to modulate the gut microbiome composition and target the relevant metabolic pathways of obesity and obesity-related metabolic diseases.

引用

页数：12

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