A high-coverage Neandertal genome from Vindija Cave in Croatia

被引：334

作者：

Pruefer, Kay ^{[1
]}

de Filippo, Cesare ^{[1
]}

Grote, Steffi ^{[1
]}

Mafessoni, Fabrizio ^{[1
]}

Korlevic, Petra ^{[1
]}

Hajdinjak, Mateja ^{[1
]}

Vernot, Benjamin ^{[1
]}

Skov, Laurits ^{[2
]}

Hsieh, Pinghsun ^{[3
]}

Peyregne, Stephane ^{[1
]}

Reher, David ^{[1
]}

Hopfe, Charlotte ^{[1
]}

Nagel, Sarah ^{[1
]}

Maricic, Tomislav ^{[1
]}

Fu, Qiaomei ^{[4
]}

Theunert, Christoph ^{[1
]}

Rogers, Rebekah

Skoglund, Pontus ^{[5
]}

Chintalapati, Manjusha ^{[1
]}

Dannemann, Michael ^{[1
]}

Nelson, Bradley J. ^{[3
]}

Key, Felix M. ^{[1
]}

Rudan, Pavao ^{[6
]}

Kucan, Zeljko ^{[6
]}

Gusic, Ivan ^{[6
]}

Golovanova, Liubov V. ^{[7
]}

Doronichev, Vladimir B. ^{[7
]}

Patterson, Nick ^{[5
]}

Reich, David ^{[5
,9
,10
]}

Eichler, Evan E. ^{[3
,11
]}

Slatkin, Montgomery ^{[8
]}

Schierup, Mikkel H. ^{[2
]}

Andres, Aida M. ^{[1
]}

Kelso, Janet ^{[1
]}

Meyer, Matthias ^{[1
]}

Paabo, Svante ^{[1
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany

[2] Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark

[3] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA

[4] Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China

[5] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[6] Croatian Acad Sci & Arts, Anthropol Ctr, Zagreb 10000, Croatia

[7] ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia

[8] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[9] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA

[10] Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA

[11] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

来源：

SCIENCE | 2017年 / 358卷 / 6363期

基金：

美国国家卫生研究院; 欧洲研究理事会; 中国国家自然科学基金; 美国国家科学基金会;

关键词：

MODERN HUMANS; ADMIXTURE; SEQUENCE; ANCIENT; DNA; INTROGRESSION; POPULATIONS; ANCESTRY;

D O I：

10.1126/science.aao1887

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from similar to 50,000 years ago from Vindija Cave, Croatia, to similar to 30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.

引用

页码：655 / 658

页数：4

共 50 条

[1] A high-coverage Neandertal genome from Chagyrskaya Cave
Mafessoni, Fabrizio
Grote, Steffi
de Filippo, Cesare
Slon, Viviane
Kolobova, Kseniya A.
Viola, Bence
Markin, Sergey, V
Chintalapati, Manjusha
Peyregne, Stephane
Skov, Laurits
Skoglund, Pontus
Krivoshapkin, Andrey, I
Derevianko, Anatoly P.
Meyer, Matthias
Kelso, Janet
Peter, Benjamin
Pruefer, Kay
Paeaebo, Svante
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (26) : 15132 - 15136
[2] Is the Late Neandertal mandibular sample from Vindija Cave (Croatia) biased?
Kesterke, Matthew J.
Ahern, James C. M.
[J]. COLLEGIUM ANTROPOLOGICUM, 2007, 31 (02) : 365 - 373
[3] The late Neandertal supraorbital fossils from Vindija Cave, Croatia: a biased sample?
Ahern, JCM
Lee, SH
Hawks, JD
[J]. JOURNAL OF HUMAN EVOLUTION, 2002, 43 (03) : 419 - 432
[4] The evidence from Vindija Cave (Croatia) reveals diversity of Neandertal behaviour in Europe
Patou-Mathis, Marylene
Karavanic, Ivor
Smith, Fred H.
[J]. QUATERNARY INTERNATIONAL, 2018, 494 : 314 - 326
[5] Taphonomy of lower vertebrates from Vindija cave (Croatia): delicacy on the Neandertal table or animal prey?
Paunovic, M
Smith, FH
[J]. JOURNAL OF HUMAN EVOLUTION, 2002, 42 (03) : A27 - A27
[6] Vindija Cave (Croatia) and the Nature of Neandertal-Early Modern European Introgression
Smith, Fred H.
Karavanic, Ivor
Lenardic, Jadranka Mauch
Radovic, Sinisa
Jankovic, Ivor
[J]. AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY, 2024, 183 : 169 - 170
[7] UPPER PLEISTOCENE HUMAN REMAINS FROM VINDIJA CAVE, CROATIA, YUGOSLAVIA
WOLPOFF, MH
SMITH, FH
MALEZ, M
RADOVCIC, J
RUKAVINA, D
[J]. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 1981, 54 (04) : 499 - 545
[8] A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Meyer, Matthias
Kircher, Martin
Gansauge, Marie-Theres
Li, Heng
Racimo, Fernando
Mallick, Swapan
Schraiber, Joshua G.
Jay, Flora
Pruefer, Kay
de Filippo, Cesare
Sudmant, Peter H.
Alkan, Can
Fu, Qiaomei
Do, Ron
Rohland, Nadin
Tandon, Arti
Siebauer, Michael
Green, Richard E.
Bryc, Katarzyna
Briggs, Adrian W.
Stenzel, Udo
Dabney, Jesse
Shendure, Jay
Kitzman, Jacob
Hammer, Michael F.
Shunkov, Michael V.
Derevianko, Anatoli P.
Patterson, Nick
Andres, Aida M.
Eichler, Evan E.
Slatkin, Montgomery
Reich, David
Kelso, Janet
Paeaebo, Svante
[J]. SCIENCE, 2012, 338 (6104) : 222 - 226
[9] New discoveries and interpretations of hominid fossils and artifacts from Vindija Cave, Croatia
Ahern, JCM
Karavanic, I
Paunovic, M
Jankovic, I
Smith, FH
[J]. JOURNAL OF HUMAN EVOLUTION, 2004, 46 (01) : 27 - 67
[10] ADDITIONAL UPPER PLEISTOCENE HUMAN REMAINS FROM VINDIJA CAVE, CROATIA, YUGOSLAVIA
SMITH, FH
BOYD, DC
MALEZ, M
[J]. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 1985, 68 (03) : 375 - 383

← 1 2 3 4 5 →