Institutional Experience With Clofarabine and Cytarabine in Relapsed Pediatric Acute Myeloid Leukemia

被引：3
|
作者：
Moreno, Lucas [1 ]
Maria Fernandez-Navarro, Jose [1 ]
del Mar Andres, Maria [1 ]
Bautista, Francisco [1 ]
Tasso, Maria [2 ]
Verdeguer, Amparo [1 ]
机构：
[1] Hosp Univ Infantil La Fe, Unidad Oncol Pediat, Valencia 46009, Spain
[2] Hosp Gen Univ, Unidad Oncol Pediat, Alicante, Spain
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2012年 / 34卷 / 01期
关键词：
clofarabine; cytarabine; acute myeloid leukemia; children; GEMTUZUMAB OZOGAMICIN; PHASE-II; CHILDREN; THERAPY; OLDER; 1ST; AML;
D O I：
10.1097/MPH.0b013e31820fee1d
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytarabine (1000 mg/m(2)/d intravenous for 5d) and clofarabine (40 mg/m(2)/d intravenous for 5d) were given every 28 days to 9 children with relapsed acute myeloid leukemia at our institution. Among 19 courses, there were 18 infectious episodes. Median hospitalization time was 13 days (7.7 to 30.5d) per cycle. Hepatobiliary abnormalities included alanine aminotransferase/aspartate aminotransferase elevation and hyperbilirubinemia. Four patients achieved complete remission (one after an earlier allogeneic Haematopoietic Progenitor Cell Transplant). Four patients are alive disease free. In summary, a proportion of children responded and was able to receive allogeneic Haematopoietic Progenitor Cell Transplant. Side effects were tolerable, although hospitalization time was prolonged.
引用
收藏
页码：E17 / E21
页数：5
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