Lignans from Euphorbia hirta L.

被引：7

作者：

Zhang, Ling ^{[1
]}

Wang, Xiao-Ling ^{[2
]}

Wang, Bin ^{[1
]}

Zhang, Long-Teng ^{[1
]}

Gao, Hui-Min ^{[1
]}

Shen, Tao ^{[1
]}

Lou, Hong-Xiang ^{[1
]}

Ren, Dong-Mei ^{[1
]}

Wang, Xiao-Ning ^{[1
]}

机构：

[1] Shandong Univ, Dept Nat Prod Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 West Wen Hua Rd, Jinan 250012, Peoples R China

[2] Shandong Univ, Hosp 2, Jinan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Anti-proliferative activity; ECD calculation; Euphorbia hirta L; HR-ESI-MS; Lignans; NMR; CIRCULAR-DICHROISM; PHYLLANTHUS; DITERPENOIDS; GROWTH; PLANTS;

D O I：

10.1080/14786419.2020.1761358

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Five new lignans, euphorhirtins A-D (1-4), 5-methoxyvirgatusin (5), three artefacts, 7S-ethoxyisolintetralin (6), 7R-ethoxyisolintetralin (7), and 7R-ethoxy-3-methoxyisolintetralin (8), together with 13 known ones (9-21) were isolated from the medicinal plant Euphorbia hirta L. The structures of the compounds were elucidated by means of extensive spectroscopic analysis, including 1D and 2D NMR and HR-ESI-MS experiments. The absolute configurations of compound 1 was determined by ECD calculation. The isolates were evaluated for their inhibitory effects against the proliferation of the cancer cell lines (Hep G2, A549, and DU145) and compounds 14 and 18 showed inhibitory activity against the Hep G2 cells with IC50 values 7.2 +/- 0.17 and 8.5 +/- 0.36 mu M.

引用

页码：26 / 36

页数：11

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