Measurement and Correlation of Solubility of Nitrendipine in Supercritical Carbon Dioxide With and Without Ethanol Cosolvent

被引：18
|
作者：
Zhan, Shiping [1 ]
Cui, Liyun [1 ]
Zhao, Qicheng [1 ]
Chen, Li [1 ]
Wang, Jingchang [1 ]
Chen, Shuhua [1 ]
Ding, Shiqiang [1 ]
机构：
[1] Dalian Univ, Coll Environm & Chem Engn, Dalian 116012, Peoples R China
来源：
JOURNAL OF SOLUTION CHEMISTRY | 2015年 / 44卷 / 01期
关键词：
Nitrendipine solubility; Supercritical carbon dioxide; Cosolvent; Semi-empirical model; EQUATION-OF-STATE; SOLUTE SOLUBILITY; ACID; SOLIDS; PREDICTION; LIQUIDS; MIXTURE; POINT;
D O I：
10.1007/s10953-014-0262-4
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The solubilities of nitrendipine in supercritical carbon dioxide (ScCO2) and in the presence of 1, 3, 5, and 7 mol.% ethanol, were measured at 308, 318, and 328 K over a pressure range of 8-20 MPa. The experimental results reveal that the solubility increased with increasing pressure; the effect of temperature was more complex with or without cosolvent. The solubilities obtained in pure ScCO2 are relatively low, and they were successfully correlated by two semi-empirical models (Chrastil, Sung and Shim (SS) models). The solubility is increased significantly with ethanol as cosolvent, and these data were also correlated well using the modified M,ndez-Santiago and Teja (M-ST) models.
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页码：1 / 15
页数：15
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