Grading of renal cell carcinoma by 3D morphological analysis of cell nuclei

被引：18
|
作者：
Choi, Hyun-Ju
Choi, Heung-Kook [1 ]
机构：
[1] Inje Univ, Sch Comp Engn, Gimhae, South Korea
[2] Pusan Natl Univ, Sch Med, BK21 Med Sci Educ Ctr, Pusan 609735, South Korea
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 2007年 / 37卷 / 09期
关键词：
renal cell carcinoma; nuclear grading system; confocal laser scanning microscopy; 3D visualization; 3D quantitative analysis; 3D feature extraction;
D O I：
10.1016/j.compbiomed.2006.12.008
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This study attempted to develop a method for 3D visualization and quantitative analysis of cell nuclei for renal cell carcinoma (RCC) grading and evaluated the feasibility of such quantitative analysis. We compared the correct classification rate (CCR) for each of the classifiers based on the 2D features of cell nuclei (diameter, area, perimeter, and circularity) and the 3D features of cell nuclei (volume, surface area, and spherical shape factor). The results showed that the classifier using the 3D features provided better results for grading. Our method could overcome the limitations inherent in 2D analysis and could improve the accuracy and reproducibility of quantification of cell nuclei. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1334 / 1341
页数：8
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