Effect of aqueous extract of garlic and licorice on Carbon Tetra Chloride induced Liver fibrosis by evaluating serum Aspartate Amino Transferase (AST) and Serum Alanine Amino Transferase (ALT)

Background: Hepatic fibrosis results from various chronic insults such as chronic hepatitis B and C, parasitic disease, autoimmune hepatitis, nonalcoholic steatohepatitis (NASH) and hereditary metal overload e.g. iron and cupper and it is linked with remarkable morbidity and mortality. Aim: To evaluate and compare the antifibrotic effect of Aqueous Garlic extract and Licorice Aqueous extract on carbon tetrachloride induced hepatic fibrosis in rats. Method: 4 groups of rats were taken. In group A and group B, rats were given injection of normal saline intraperitonally. In group C and D, rats were given injection of Aqueous garlic extract (AGE) and licorice aqueous extract (LAE) 01 ml / Kg body weight of rat /day intraperitonally for next four weeks respectively. At the end, all rats were sacrificed. Blood and liver were taken for biochemical examination. Results: This study results showed that the use of aqueous garlic extract and aqueous licorice extract reduces 0014 induced liver fibrosis in rats.