Development and applications of whole cell biosensors for ecotoxicity testing

被引：36

作者：

Pasco, Neil F. ^{[1
]}

Weld, Richard J. ^{[1
]}

Hay, Joanne M. ^{[1
]}

Gooneratne, Ravi ^{[2
]}

机构：

[1] Lincoln Ventures Ltd, Christchurch 7640, New Zealand

[2] Lincoln Univ, Canterbury 7647, New Zealand

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2011年 / 400卷 / 04期

关键词：

Microbial biosensors; Environmental toxicity; Broad response; Specific response; Engineered response; BIOCHEMICAL OXYGEN-DEMAND; MICROBIAL FUEL-CELL; PSEUDOMONAS-PUTIDA [!text type='JS']JS[!/text]444; OPTICAL-FIBER BIOSENSOR; WASTE-WATER; RAPID-DETERMINATION; BOD SENSOR; ESCHERICHIA-COLI; DICTYOSTELIUM-DISCOIDEUM; BACTERIAL BIOSENSORS;

D O I：

10.1007/s00216-011-4663-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Whole cell biosensors are the focus of considerable and increasing interest worldwide as methods for detecting and quantifying environmental toxicity, including biochemical oxygen demand (BOD), heavy metals, antibiotics, pesticides and herbicides. This review follows the development of whole cell biosensors from attempts to utilise changes in cellular metabolism to determine BOD and general toxicity, through the exploitation of unique metabolic pathways to detect specific toxicants, to the increasingly widespread use of genetic engineering to build new, and modify existing, sensing pathways.

引用

页码：931 / 945

页数：15

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