RETRACTED: si-RNA-Mediated Knockdown of PDLIM5 Suppresses Gastric Cancer Cell Proliferation in Vitro (Retracted article. See vol. 92, pg. 2035, 2018)

被引：15

作者：

Li, Yanliang ^{[1
]}

Gao, Yongsheng ^{[2
]}

Xu, Yue ^{[3
]}

Sun, Xianjun ^{[1
]}

Song, Xilin ^{[1
]}

Ma, Heng ^{[1
]}

Yang, Mingshan ^{[4
]}

机构：

[1] Shandong Tumor Hosp, Dept Gastrointestinal Surg, Jinan 250117, Peoples R China

[2] Shandong Tumor Hosp, Dept Pathol, Jinan 250117, Peoples R China

[3] Wucheng Peoples Hosp, Dept Intens Care Unit, Wucheng 253300, Shandong, Peoples R China

[4] Shandong Tumor Hosp, Dept Urol, Jinan 250117, Peoples R China

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2015年 / 85卷 / 04期

关键词：

cell cycle; gastric cancer; growth; PDLIM5; si-RNA; BIPOLAR DISORDER; GROWTH; GENE; ASSOCIATION; PROGRESSION;

D O I：

10.1111/cbdd.12428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is the second most prominent cause of cancer mortality in the world. This study was designed to identify the possible use of si-RNA-mediated PDLIM5 gene silencing as a therapeutic tool for gastric cancer. Expression levels of PDLIM5 were detected in several gastric cancer cell lines using Western blot and qRT-PCR. We found PDLIM5 is highly expressed in all cultured gastric cancer cell lines. Small interfering RNA (si-RNA) was then employed to knock down PDLIM5 expression in MGC80-3 gastric cancer cells. Knockdown of PDLIM5 significantly inhibited cell proliferation and colony formation. Moreover, the absence of PDLIM5 in MGC80-3 cells led to S phase cell cycle arrest and apoptosis. This study highlights the critical role of PDLIM5 in gastric cancer cell growth and suggests that si-RNA-mediated silencing of PDLIM5 might serve as a potential therapeutic approach for the treatment of gastric cancer.

引用

页码：447 / 453

页数：7

共 50 条

[1] RETRACTION: si-RNA-Mediated Knockdown of PDLIM5 Suppresses Gastric Cancer Cell Proliferation in Vitro (Retraction of Vol 85, Pg 447, 2015)
Li, Yanliang
Gao, Yongsheng
Xu, Yue
Sun, Xianjun
Song, Xilin
Ma, Heng
Yang, Mingshan
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 92 (06) : 2035 - 2035
[2] RETRACTED: Mouse models of intestinal inflammation and cancer (Retracted article. See vol. 92, pg. 3441, 2018)
Westbrook, Aya M.
Szakmary, Akos
Schiestl, Robert H.
ARCHIVES OF TOXICOLOGY, 2016, 90 (09) : 2109 - 2130
[3] RETRACTED: The weapons effect (Retracted article. See vol. 22, pg. 96, 2018)
Benjamin, Arlin James, Jr.
Bushman, Brad J.
CURRENT OPINION IN PSYCHOLOGY, 2018, 19 : 93 - 97
[4] RETRACTED: Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo (Retracted article. See vol. 17, pg. 6927, 2018)
Zhang, Xianqing
Hu, Xingbin
Mu, Shijie
Zhan, Yonghua
An, Qunxing
Liu, Zhixin
Huang, Xiaofeng
MOLECULAR MEDICINE REPORTS, 2014, 10 (03) : 1184 - 1194
[5] RETRACTED: Pediatric sarcomas (Review)(Retracted article. See vol. 15, pg. 5391, 2018)
Cao, Junhua
An, Qi
Wang, Lei
ONCOLOGY LETTERS, 2018, 15 (02) : 1397 - 1402
[6] RETRACTED: Bioethics and medical education (Retracted article. See vol. 63, pg. 38, 2018)
Sajid, M. S.
SCOTTISH MEDICAL JOURNAL, 2008, 53 (02) : 62 - 63
[7] RETRACTED: A Model for Ethical Reasoning (Retracted article. See vol. 22, pg. 420, 2018)
Sternberg, Robert J.
REVIEW OF GENERAL PSYCHOLOGY, 2012, 16 (04) : 319 - 326
[8] RETRACTED: RNA editing in human cancer: review (Retracted article. See vol. 118, pg. 337, 2010)
Skarda, Jozef
Amariglio, Ninette
Rechavi, Gideon
APMIS, 2009, 117 (08) : 551 - 557
[9] RETRACTED: Inhibition of GPR137 suppresses proliferation of medulloblastoma cells in vitro (Retracted article. See vol. 70, pg. 1557, 2023)
Wang, Chengfeng
Liang, Qinchuan
Chen, Guangming
Jing, Junjie
Wang, Shousen
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2015, 62 (06) : 868 - 873
[10] RETRACTED: Cryptomycota: the missing link (Retracted article. See vol. 5, pg. 883, 2014)
Bolla, Krishna
Ashforth, Elizabeth Jane
PROTEIN & CELL, 2012, 3 (03) : 161 - 162

← 1 2 3 4 5 →