INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner

被引：6
|
作者：
Pan, XF
Zhai, L
Sun, R
Li, XY
Zeng, XL [1 ]
机构：
[1] NE Normal Univ, Sch Life Sci, Inst Genet & Cytol, Changchun 130024, Jilin, Peoples R China
[2] Changchun Teachers Coll, Sch Life Sci, Changchun 130024, Jilin, Peoples R China
[3] Jilin Univ, Inst Phys Educ, Dept Human Sports, Changchun 130021, Jilin, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 337卷 / 04期
基金：
中国国家自然科学基金;
关键词：
INI1/hSNF5/BAF47; repression; c-fos; transcription; histone deacetylases;
D O I：
10.1016/j.bbrc.2005.09.155
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
INI1/hSNF5/BAF47 is a core component of the hSWI/SNF ATP-dependent chromatin-remodeling complex. It has been suggested that INI1/hSNF5/BAF47 contributes to the regulation of many genes. In this report, we showed that the overexpression of INI1/hSNF5/BAF47 repressed c-fos promoter activity and endogenous c-fos transcription in 293T cells, and the siRNA targeting INI1/hSNF5/BAF47 (siINI1) reversed the inhibitory effect. Histone deacetylation by histone deacetylases (HDACs) was necessary for the repression of c-fos transcription by INI1/hSNF5/BAF47. HDAC and INJI/hSNF5/BAF47 functioned together to suppress c-fos transcription. ChIP experiments demonstrated that INI1/hSNF5/BAF47 could be recruited to the region of c-fos promoter to reduce histone acetylation. Altogether, these data show that INI1/hSNF5/BAF47 represses c-jbs transcription via a histone deacetylase (HDAC)-dependent manner. (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：1052 / 1058
页数：7
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