Pro-nutritional factors in food: the cancer preventive potential of Brussels sprouts studied in human volunteers

被引：0

作者：

Verhagen, H ^{[1
]}

van Poppel, G ^{[1
]}

机构：

[1] TNO, Nutr & Food Res Inst, NL-3700 AJ Zeist, Netherlands

来源：

RECENT ADVANCES OF RESEARCH IN ANTINUTRITIONAL FACTORS IN LEGUME SEEDS AND RAPESEED | 1998年 / 93期

关键词：

glucosinolates; biomarkers; Brussels sprouts; functional foods; glutathione-S-transferase; 8-oxo-7,8-2 '-deoxyguanosine; oxidative DNA-damage;

D O I：

暂无

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Two short-term intervention studies were conducted with glucosinolate-containing Brussels sprouts. At the end of the intervention period male volunteers, but not females, had a higher content of the enzyme glutahione-S-transferase (GST)-alpha in their blood. This enzyme is mainly involved in detoxification of xenobiotics. In rectal biopsies we found induction of GST-alpha and GST-pi. Moreover, we found that in the male volunteers there was decreased excretion of 8-oxo-7,8-2'-deoxyguanosine (8-oxodG) in the urine, suggesting protection against oxidative DNA-damage. This data show that 'established' antinutritional factors in food can have pronutritional cancer prevention potential.

引用

页码：151 / 154

页数：4