Poly(ether ester amide) microspheres for protein delivery: Influence of copolymer composition on technological and biological properties

被引：5
|
作者：
Ostacolo, Luisanna [1 ]
Russo, Paola [1 ]
De Rosa, Giuseppe [1 ]
La Rotonda, Maria Immacolata [1 ]
Maglio, Giovanni [2 ]
Nese, Giuseppe [2 ]
Spagnuolo, Gianrico [3 ]
Rengo, Sandro [3 ]
Oliva, Adriana [4 ]
Quaglia, Fabiana [1 ]
机构：
[1] Univ Naples Federico 2, Dept Pharmaceut & Toxicol Chem, I-80131 Naples, Italy
[2] Univ Naples Federico 2, Dept Chem Paolo Corradini, I-80126 Naples, Italy
[3] Univ Naples Federico 2, Dept Oral & Maxillofacial Sci, I-80131 Naples, Italy
[4] Univ Naples 2, Dept Biochem & Biophys F Cedrangolo, I-80138 Naples, Italy
来源：
MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 07期
关键词：
poly(epsilon-caprolactone); microspheres; proteins;
D O I：
10.1002/mabi.200700303
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The production of PEEA microspheres with potential as carriers for protein oral delivery is described. PEEAs with different hydrophilicity were synthesized and characterized. Experiments showed that an increase in copolymer hydrophilicity gave particles less prone to cell interaction. BSA release profiles from PEEA microspheres demonstrated that an increase in polymer hydrophilicity was useful in limiting protein burst and modulating drug delivery rate by increasing PEEA degradability. These results show that fine-tuning of the hydrophilic/hydrophobic properties of PCL is essential for the formulation protein-loaded microspheres with specific properties.
引用
收藏
页码：682 / 689
页数：8
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