Leptin in depressed women: Cross-sectional and longitudinal data from an epidemiologic study

被引:82
|
作者
Pasco, Julie A. [1 ]
Jacka, Felice N. [1 ]
Williams, Lana J. [1 ]
Henry, Margaret J. [1 ]
Nicholson, Geoffrey C. [1 ]
Kotowicz, Mark A. [1 ]
Berk, Michael [1 ]
机构
[1] Univ Melbourne, Dept Clin & Biomed Sci, Geelong, Vic 3220, Australia
基金
英国医学研究理事会;
关键词
leptin; depression; dysthymia; risk factor; body mass index; epidemiology;
D O I
10.1016/j.jad.2007.07.024
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: There is conflicting evidence regarding levels of leptin in depression. In this study we aimed to investigate the relationship between serum leptin level and depression in a community sample of women using both cross-sectional and longitudinal data. Methods: From among 510 women aged 20-78 yr, 83 were identified with a lifetime history of major depressive disorder or dysthymia, ascertained using the Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition (SCID-I/NP). Serum leptin levels were measured by radioimmunoassay. Medication use and lifestyle were self-reported and body mass index (BMI) determined from measures of height and weight. Results: Using multiple linear regression, serum leptin levels were greater among women with a lifetime history of depression compared to women without any history of depression, independent of BMI. Adjusted geometric mean values of serum leptin were 16.37 (95%CI 14.70-18.23) ng/mL for depressed and 14.46 (95%CI 13.79-15.16) ng/mL for non-depressed women (P=0.039). The hazard ratio (HR) for a de novo depressive disorder over five years increased 2.56-fold for each standard deviation increase in log-transformed serum leptin among non-smokers and this was not explained by differences in BMI, medications or other lifestyle factors (HR=2.56, 95%CI 1.52-4.30). No association was observed for smokers. Limitations: There is potential for unrecognised confounding, recall bias and transient changes in body composition. Conclusion: Women with a lifetime history of depression have elevated levels of serum leptin, and elevated serum leptin predicts subsequent development of a depressive disorder. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:221 / 225
页数:5
相关论文
共 50 条
  • [1] Depressed Kallikrein Generation in Women With Preeclampsia: A Matched Cross-Sectional Study
    Godtfredsen, Anne Cathrine
    Gram, Jorgen Brodersen
    Pham, Stephanie Thuy Duong
    Dolleris, Britta Blume
    Jorgensen, Jan Stener
    Sidelmann, Johannes Jakobsen
    Palarasah, Yaseelan
    [J]. FRONTIERS IN MEDICINE, 2022, 9
  • [2] Serum lipids, leptin, and soluble leptin receptor in alcohol dependence: A cross-sectional and longitudinal study
    Weinland, Christian
    Tanovska, Petya
    Kornhuber, Johannes
    Muehle, Christiane
    Lenz, Bernd
    [J]. DRUG AND ALCOHOL DEPENDENCE, 2020, 209
  • [3] LONGITUDINAL THEORY AND CROSS-SECTIONAL DATA
    KENDLER, TS
    [J]. BULLETIN OF THE PSYCHONOMIC SOCIETY, 1979, 14 (04) : 251 - 251
  • [4] Integrating clinical data from cross-sectional and longitudinal studies
    Li, Yuanxi
    Tucker, Allan
    [J]. 2014 IEEE 27TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS), 2014, : 465 - +
  • [5] Is my study cross-sectional or longitudinal?
    Martinez, Luis Alberto Corona
    Hernandez, Mercedes Fonseca
    [J]. MEDISUR-REVISTA DE CIENCIAS MEDICAS DE CIENFUEGOS, 2023, 21 (04): : 931 - 934
  • [6] ARE OLD-PEOPLE MORE DEPRESSED - CROSS-SECTIONAL DATA ON CENTER FOR EPIDEMIOLOGIC STUDIES DEPRESSION SCALE FACTORS
    GATZ, M
    HURWICZ, ML
    [J]. PSYCHOLOGY AND AGING, 1990, 5 (02) : 284 - 290
  • [7] COMPONENT ANALYSIS IN CROSS-SECTIONAL AND LONGITUDINAL DATA
    MILLSAP, RE
    MEREDITH, W
    [J]. PSYCHOMETRIKA, 1988, 53 (01) : 123 - 134
  • [8] CROSS-SECTIONAL AND LONGITUDINAL COMPARISONS OF BIPOLAR AND UNIPOLAR DEPRESSED GROUPS ON MMPI
    DONNELLY, EF
    MURPHY, DL
    GOODWIN, FK
    [J]. JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1976, 44 (02) : 233 - 237
  • [9] FROM CROSS-SECTIONAL TO LONGITUDINAL MEDICINE
    Werge, T.
    [J]. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2022, 66 (8-9) : 670 - 670
  • [10] Symptoms of Depressed Mood, Disturbed Sleep, and Sexual Problems in Midlife Women: Cross-Sectional Data from the Study of Women's Health Across the Nation
    Prairie, Beth A.
    Wisniewski, Stephen R.
    Luther, James
    Hess, Rachel
    Thurston, Rebecca C.
    Wisner, Katherine L.
    Bromberger, Joyce T.
    [J]. JOURNAL OF WOMENS HEALTH, 2015, 24 (02) : 119 - 126