Regulation of cellulose-based adsorbent granule morphology

The hydrophilic nature, biocompatibility and absence of nonspecific adsorption render cellulose-based adsorbents an attractive chromatographic medium for the isolation and purification of biopreparations. The analysis of the formation methods of cellulose gels for liquid chromatography revealed potential possibilities to regulate the morphological structure of cellulose granules. New methods of the preparation of cellulose adsorbents including those which enable one to regulate granule morphology are developed and discussed in more detail. The chromatographic behaviour of adsorbents of different morphological structure is also analysed.