Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice

被引：37
|
作者：
Fiorucci, Stefano [1 ]
Mencarelli, Andrea [1 ]
Cipriani, Sabrina [1 ]
Renga, Barbara [1 ]
Palladino, Giuseppe [1 ]
Santucci, Luca [2 ]
Distrutti, Eleonora [2 ]
机构：
[1] Univ Perugia, Dipartimento Med Clin Sperimentale, Fac Med & Chirurg, I-06122 Perugia, Italy
[2] Osped Santa Maria Misericordia, Azienda Osped Perugia, Perugia, Italy
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2011年 / 164卷 / 08期
关键词：
Acetyl salicylic acid; bile acids; cystathionine-?- lyase; farnesoid X receptor; hydrogen sulphide; nitric oxide; non-steroidal anti-inflammatory drugs; nuclear receptors; NUCLEAR RECEPTOR; BILE-ACID; DISRUPTION; INHIBITORS; TOXICITY; LIGANDS; COXIBS; NSAIDS;
D O I：
10.1111/j.1476-5381.2011.01481.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
BACKGROUND AND PURPOSE Low doses of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage. The farnesoid X receptor (FXR) is a bile acid sensor essential for maintenance of intestinal homeostasis. Here, we have investigated whether FXR is required for mucosal protection in models of gastrointestinal injury caused by ASA and NSAIDs and if FXR activation has potential in the treatment or prevention of gastrointestinal injury caused by these agents.
引用
收藏
页码：1929 / 1938
页数：10
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