Phase Ib study of neoadjuvant chemoradiation (CRT) with midostaurin, 5-fluorouracil (5-FU) and radiation (XRT) for locally advanced rectal cancer: Sensitization of RAS mutant tumors

被引:4
|
作者
Hong, Theodore S.
Wo, Jennifer Yon-Li
Ryan, David P.
Zheng, Hui
Borger, Darrell R.
Kwak, Eunice Lee
Allen, Jill N.
Berger, David L.
Rattner, David W.
Cusack, James C.
Gemma, Angelo J.
Mamon, Harvey J.
Eyler, Christine E.
Shellito, Paul C.
Zhu, Andrew X.
Goyalx, Lipika
Goyal, Lipika
Clark, Jeffrey W.
Willers, Henning
Haigis, Kevin M.
机构
[1] NRG Oncol, Boston, MA USA
[2] Massachusetts Gen Hosp, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Harvard Med Sch, Boston, MA 02114 USA
[4] Dana Farber Canc Inst, Boston, MA 02115 USA
[5] Massachusetts Gen Hosp, Harvard Med Sch, Ctr Canc, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Mol Pathol Unit, Charlestown, MA USA
关键词
D O I
10.1200/JCO.2018.36.15_suppl.e15674
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e15674
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Phase I study of neoadjuvant 5-fluorouracil (5FU) chemoradiation (CRT) and trametinib in patients with locally advanced rectal cancers (LARC)
    Wu, Christina Sing-Ying
    Williams, Terence M.
    Wei, Lai
    Umar, Hamida
    Mikhail, Sameh
    Ciombor, Kristen Keon
    Noonan, Anne M.
    Roychowdhury, Sameek
    El-Dika, Samer S.
    Krishna, Somashekar
    Upchurch, Bennie
    McCarthy, Sean T.
    Arnold, Mark
    Harzman, Alan
    Abdel-Misih, Sherif
    Cirocco, William
    Traugott, Amber
    Bekaii-Saab, Tanios S.
    Wuthrick, Evan John
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (04)
  • [2] Neoadjuvant chemoradiation with capecitabine versus infusional 5-fluorouracil (5-FU) for locally advanced rectal cancer: A matched pair analysis
    Das, P
    Lin, EH
    Bhatia, S
    Skibber, JM
    Rodriguez-Bigas, MA
    Feig, BW
    Hoff, PM
    Eng, C
    Wolff, RA
    Krishnan, S
    Janjan, NA
    Crane, CH
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 63 (02): : S164 - S164
  • [3] A phase I/II study of preoperative oxaliplatin (0), 5-fluorouracil (5-FU), and external beam radiation therapy (XRT) in locally advanced rectal cancer: CALGB 89901.
    Ryan, DP
    Niedzwiecki, D
    Hollis, D
    Miedema, BE
    Wadler, S
    Tepper, JE
    Mayer, RJ
    JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (14) : 260S - 260S
  • [4] Chemoradiation in locally advanced rectal cancer using bolus 5-fluorouracil
    Mawdsley, S
    Glynne-Jones, R
    BRITISH JOURNAL OF CANCER, 2003, 88 : S21 - S21
  • [5] PROTRACTED INFUSIONAL 5-FLUOROURACIL (5-FU) AS NEOADJUVANT AND RADIATION SENSITIZOR IN GASTROINTESTINAL CANCER
    LOKICH, J
    RICH, T
    CHAFFEY, J
    CANCER DRUG DELIVERY, 1986, 3 (01): : 67 - 67
  • [6] Clinical outcome of neoadjuvant chemoradiation therapy with oxaliplatin and capecitabine or 5-fluorouracil for locally advanced rectal cancer
    Lu, Jun-Yang
    Xiao, Yi
    Qiu, Hui-Zhong
    Wu, Bin
    Lin, Guo-Le
    Xu, Lai
    Zhang, Guan-Nan
    Hu, Ke
    JOURNAL OF SURGICAL ONCOLOGY, 2013, 108 (04) : 213 - 219
  • [7] A Compartive Study of Capecitabine and Oxaliplatin versus 5-fluorouracil in Neoadjuvant Chemoradiation for Locally Advanced Rectal Carcinoma
    Soliman, A.
    Ibrahim, A.
    Khalaf, M.
    Abdelhady, H.
    Attia, N.
    ANNALS OF ONCOLOGY, 2016, 27 : 92 - 93
  • [8] Neoadjuvant radiochemotherapy with 5-FU plus Oxaliplatin for locally advanced rectal cancer
    Roedel, C.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2012, 188 (05) : 446 - 447
  • [9] Feasibility of preoperative radiotherapy with weekly oxaliplatin (OXA), 5-fluorouracil (5-FU) continuous infusion in the treatment of locally advanced rectal cancer: Phase I study
    Friso, ML
    Aschele, C
    Pucciarelli, S
    Fabris, G
    Martella, B
    Munegato, M
    Ranzato, R
    Neri, D
    Fasano, C
    Lora, O
    Loreggian, L
    Toppan, P
    Muzzio, PC
    Sotti, G
    TUMORI, 2001, 87 (04) : S109 - S109
  • [10] Capecitabine and oxaliplatin versus 5-fluorouracil in the neoadjuvant chemoradiation for patients with locally advanced rectal carcinoma: A comparative study
    Amal, Ibrahim
    Hossam, Abdelhady
    Ahmad, Soliman
    Marwa, Khalaf
    Dalia, Osama
    Khalid, Rezk
    ANNALS OF ONCOLOGY, 2017, 28