Chiral syntheses of dihydroxyamino acid moieties of AI-77-B and calyculins from D-glucosamine

被引：0
|
作者：
Shinozaki, K [1 ]
Mizuno, K [1 ]
Wakamatsu, H [1 ]
Masaki, Y [1 ]
机构：
[1] GIFU PHARMACEUT UNIV, GIFU 502, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 10期
关键词：
D-glucosamine; chiral pool; (2S,3S,4S)-2,3-dihydroxy-4-aminohexanedioic acid; (2S,3S,4S)-2,3-dihydroxy-4-dimethylamino-5-methoxypentanoic acid; synthesis;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Manipulation of cis (4S,5S)-4,5-disubstituted 2-oxazolidinones (4, 5), derived easily from D-glucosamine (1) as a chiral pool, including degradation of the C6-carbon and/or one-carbon homologation at the C1-position allowed chiral syntheses of (2S,3S)-dihydroxy-(4S)-amino acid moieties (6-8), which are important structural components of a gastroprotective substance, AI-77-B, and a group of antitumor substances, calyculins.
引用
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页码：1823 / 1830
页数：8
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