Prospects for Minocycline Neuroprotection

被引：204
|
作者：
Plane, Jennifer M. [1 ]
Shen, Yan [1 ]
Pleasure, David E. [2 ,3 ]
Deng, Wenbin [1 ,3 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Cell Biol & Human Anat, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Sch Med, Dept Pediat & Neurol, Sacramento, CA 95817 USA
[3] Shriners Hosp Crippled Children, Inst Pediat Regenerat Med, Sacramento, CA USA
来源：
ARCHIVES OF NEUROLOGY | 2010年 / 67卷 / 12期
基金：
美国国家卫生研究院;
关键词：
NIGROSTRIATAL DOPAMINERGIC NEURODEGENERATION; AMYOTROPHIC-LATERAL-SCLEROSIS; WHITE-MATTER INJURY; HUNTINGTONS-DISEASE; MULTIPLE-SCLEROSIS; DOUBLE-BLIND; MODEL; NEUROINFLAMMATION; MOUSE; MITOCHONDRIA;
D O I：
10.1001/archneurol.2010.191
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system. Arch Neurol. 2010;67(12):1442-1448. Published online August 9, 2010. doi:10.1001/archneurol.2010.191
引用
收藏
页码：1442 / 1448
页数：7
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