Real-World Analysis of the EGFR Mutation Test in Tissue and Plasma Samples from Non-Small Cell Lung Cancer
被引:4
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作者:
Lee, Hyunwoo
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Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South KoreaSungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South Korea
Lee, Hyunwoo
[1
]
Han, Joungho
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Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South KoreaSungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South Korea
Han, Joungho
[1
]
Choi, Yoon-La
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Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South Korea
Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul 06351, South KoreaSungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South Korea
Choi, Yoon-La
[1
,2
]
机构:
[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Seoul 06351, South Korea
[2] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul 06351, South Korea
Molecular evaluation of EGFR mutation is indispensable in treating non-small cell lung cancer (NSCLC). We compared the results of EGFR analysis using tissue DNA (tDNA) and circulating tumor (ctDNA) to evaluate the feasibility of plasma as an effective material for detecting EGFR mutation and the reliability of ctDNA analysis in real-world practice settings. We enrolled 554 NSCLC cases who had undergone ctDNA EGFR analysis between January 2019 and March 2020. EGFR mutations were detected in 240 (57.3%) of the 421 cases with EGFR mutations confirmed by tDNA analysis. In multivariate analysis, the size of the largest tumor deposits, disease progression, M stage, the detectable amount of tumor tissue with EGFR mutation in distant metastasis, liver metastasis, pleural seeding, and bone metastasis (p < 0.05) were identified as independent factors affecting the detection rate of EGFR mutations in ctDNA. Survival analysis revealed ctDNA status and M stage (p < 0.001) to be independent predictors of overall survival in the multivariate analysis. Our study demonstrates that EGFR analysis using ctDNA is a useful clinical tool and can aid in therapeutic decisions in real-world practical settings. However, clinicians should be aware of the possibility of false negatives and confirm EGFR analysis using tDNA in certain situations.
机构:
Yonsei Univ, Coll Med, Div Med Oncol, Dept Internal Med,Yonsei Canc Ctr,Severance Hosp, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Coll Med, Div Med Oncol, Dept Internal Med,Yonsei Canc Ctr,Severance Hosp, 50-1 Yonsei Ro, Seoul 03722, South Korea
Heo, Su Jin
Kim, Jee Hung
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Yonsei Univ, Coll Med, Div Med Oncol, Dept Internal Med,Yonsei Canc Ctr,Severance Hosp, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Coll Med, Div Med Oncol, Dept Internal Med,Yonsei Canc Ctr,Severance Hosp, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kim, Jee Hung
Cho, Byoung Chul
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Yonsei Univ, Coll Med, Div Med Oncol, Dept Internal Med,Yonsei Canc Ctr,Severance Hosp, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Coll Med, Div Med Oncol, Dept Internal Med,Yonsei Canc Ctr,Severance Hosp, 50-1 Yonsei Ro, Seoul 03722, South Korea
机构:
Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Long, Chaolian
Li, Kun
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Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Li, Kun
Liu, Zichen
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Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Liu, Zichen
Zhang, Nana
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机构:
Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Zhang, Nana
Xing, Xuya
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Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Xing, Xuya
Xu, Liming
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机构:
Amoy Diagnost Co Ltd, Xiamen, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Xu, Liming
Gai, Fei
论文数: 0引用数: 0
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机构:
Amoy Diagnost Co Ltd, Xiamen, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Gai, Fei
Che, Nanying
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机构:
Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Beijing Chest Hosp, Dept Pathol, Bei Guan Da Jie 9, Beijing 101149, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Pathol, Beijing, Peoples R China
Che, Nanying
[J].
CANCER MEDICINE,
2023,
12
(07):
: 7982
-
7991