Photoinduced Trifluoromethylation with CF3Br as a Trifluoromethyl Source: Synthesis of α-CF3-Substituted Ketones

被引：18

作者：

Ma, Ransong ^{[1
]}

Deng, Zhoubin ^{[1
]}

Wang, Ke-Hu ^{[1
]}

Wang, Junjiao ^{[1
]}

Huang, Danfeng ^{[1
]}

Su, Yingpeng ^{[1
]}

Hu, Yulai ^{[1
,3
]}

Lv, Xiaobo ^{[2
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China

[2] Shanghai Sinofluoro Chem Co Ltd, Shanghai 201321, Peoples R China

[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ACS OMEGA | 2022年 / 7卷 / 16期

基金：

中国国家自然科学基金;

关键词：

SILYL ENOL ETHERS; PET-OXIDATIVE CYCLIZATION; ALKENES; HYDROTRIFLUOROMETHYLATION; BROMOTRIFLUOROMETHANE; REAGENTS; ALKYNES; ARENES;

D O I：

10.1021/acsomega.2c01241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and novel photoinduced trifluoromethylation employing CF3Br as a trifluoromethyl source is described. With commercially accessible fac-Ir(III)(ppy)3 as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF3Br occurs successfully. This method provides various alpha-CF3-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.

引用

页码：14357 / 14362

页数：6

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