Facile and regioselective synthesis of new fluorinated [1,2,4]-triazolo [4,3-a]pyrimidin-7(1H)-one derivatives from fluorinated alkynes

被引：7
|
作者：
Jismy, Badr [1 ]
Allouchi, Hassan [2 ]
Aweli, Monia [3 ]
Abarbri, Mohamed [1 ]
Allouch, Fatma [3 ]
机构：
[1] Fac Sci, Lab Physicochim Mat & Electrolytes Energie PCM2E, EA 6299, Ave Monge,Parc Grandmont, F-37200 Tours, France
[2] Fac Pharm, Synth & Isolement Mol BioAct SIMBA, Lab Chim Phys, EA 7502, 31 Ave Monge, F-37200 Tours, France
[3] Univ Sfax, Inst Super Biotechnol Sfax, Lab Chim Med & Environm, Sfax 3018, Tunisia
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2020年 / 229卷
关键词：
5-amino[1,2,4]triazoles; Fluorinated alkynes; One-Pot synthesis; Regioselective; Fluorinated 1,3-disubstituted[1,2,4]-triazolo[4,3-a]pyrimidin-7(1H)-ones; BETA-KETO-ESTERS; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; ANTIFUNGAL ACTIVITIES; DIRECT ACCESS; TRIAZOLES; 5-AMINO-1,2,4-TRIAZOLES; ANTIBACTERIAL; SAR;
D O I：
10.1016/j.jfluchem.2019.109390
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A mild, simple and efficient method for the regioselective synthesis of 3-substituted-1-phenyl[1,2,4]-triazolo[4,3-a]pyrimidin-7(1H)-ones bearing a perfluoroalkyl group on position 5 is reported herein. The synthetic route involved a one-pot two-step Michael addition/heterocyclization reaction with 2-aminotriazoles and fluorinated alkynes as starting materials.
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页数：7
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