α-tocopherol controls cell proliferation in the adult rat dentate gyrus

被引：12
|
作者：
Cuppini, R
Ciaroni, S
Cecchini, T
Ambrogini, P
Ferri, P
Del Grande, P
Papa, S
机构：
[1] Univ Urbino, Inst Physiol Sci, I-61029 Urbino, PS, Italy
[2] Univ Urbino, Inst Morphol Sci, I-61029 Urbino, PS, Italy
来源：
NEUROSCIENCE LETTERS | 2001年 / 303卷 / 03期
关键词：
alpha-tocopherol; 5-bromo-2 '-deoxyuridine; cell proliferation; cell death; dentate gyrus;
D O I：
10.1016/S0304-3940(01)01747-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of alpha -tocopherol on cell proliferation and proliferated cell survival was investigated in the dentate gyrus of adult rats. Adult rats were supplemented with alpha -tocopherol, injected with 5-bromo-2'-deoxyuridine (BrdU), that is incorporated into DNA during the S-phase, and killed at different time after BrdU injection. The number of newborn cells decreased after alpha -tocopherol supplementation, confirming the hypothesis that alpha -tocopherol is able to depress cell proliferation in vivo. Most newborn cells die within few days; more newborn cells survive in alpha -tocopherol-treated rats, suggesting the hypothesis that alpha -tocopherol decreases cell death. (C) 2001 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码：198 / 200
页数：3
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