Background and Aims This study aimed to examine the quality of life (QoL) and health satisfaction of undergraduate university students in Sarawak during MCO and its association with socio-demographic profiles. Methods In this cross-sectional study, QoL and satisfaction of health of 503 undergraduate university students (63.4% females) from a public university was assessed online using the World Health Organization QoL (WHOQOL)-BREF instrument. Results The overall QoL and satisfaction with health were 3.7 +/- 0.87 and 3.9 +/- 0.82, respectively. Male students showed significantly lower mean scores for the environmental domains than female students (63.37 +/- 16.21 vs 68.10 +/- 14.00, P < .01). Students who lived inside the campus (vs outside campus) showed significantly lower mean score for the physical health (61.49 +/- 13.94 vs 67.23 +/- 13.93, P < .01), environmental health (58.35 +/- 15.07 vs 70.49 +/- 13.21, P < .01), overall QoL (3.39 +/- 0.90 vs 3.84 +/- 0.83, P < .01), and satisfaction with health (3.71 +/- 0.90 vs 3.97 +/- 0.77, P < .01). Students with parent's income below RM5000 (vs parent's income more than RM5000) had significantly lower mean score for the environmental domain (65.06 +/- 14.35 vs 68.20 +/- 15.74, P < .05). Others ethnicity scored significantly lower than Bumiputera Sarawak and Malay while Bumiputera Sarawak scored significantly lower than Chinese in physical health domain (Malay = 65.73 +/- 13.40, Chinese = 63.24 +/- 15.35, Bumiputra Sarawak = 67.35 +/- 13.30, Others = 60.84 +/- 15.88, P < .05). Malay (69.99 +/- 15.20) scored significantly higher than other ethnicities (Chinese = 63.58 +/- 15.80; Bumiputera Malaysia = 65.23 +/- 13.66; others = 63.98 +/- 15.59) in environmental domain (P < .01). When comparing between religions, the results also showed there were significant differences between different religion groups in overall QoL (Islam = 3.75 +/- 0.93, Christianity = 3.77 +/- 0.79, Others = 3.34 +/- 1.14, P < .05), physical health (Islam = 65.00 +/- 13.86, Buddhism = 68.40 +/- 11.99, Christianity = 64.77 +/- 14.94, Others = 61.00 +/- 16.03, P < .05), and environmental health (Islam = 69.66 +/- 15.48, Buddhism = 64.99 +/- 11.36, Christianity = 64.87 +/- 15.61, Others = 62.13 +/- 16.28, P < .05). Conclusion By understanding university students' QoL in this global disaster, relevant authorities would provide a better rehabilitation and assistance to those affected ones.